In contrast to the outstanding performance of the machine learning approach, its adoption in industry appears to be relatively slow compared to the speed of its proliferation in a variety of business sectors. The low interpretability of a black-box-type model, such as a machine learning-based valuation model, is one reason for this. In this study, house prices in Seoul and Jeollanam Province, South Korea, were estimated using a neural network, a representative model to implement machine learning, and we attempted to interpret the resultant price estimations using an interpretability tool called a partial dependence plot. Partial dependence analysis indicated that locally optimized valuation models should be designed to enhance valuation accuracy: a land-oriented model for Seoul and a building-focused model for the Jeollanam Province. The interpretable machine learning approach is expected to catalyze the adoption of machine learning in the industry, including property valuation.